The 1998 Nobel Prize in Medicine was awarded for discovering that nitric oxide is the key signaling molecule controlling blood vessel dilation. CircO2 — by respected American manufacturer Advanced Bionutritionals — delivers a unique sublingual lozenge formula to rapidly support your NO levels and help you feel energized, sharp, and physically strong at any age.
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Take the Free Quiz →These aren't just signs of aging — they're your body's signals that it needs targeted nutritional support. If you recognize any of these, the quiz below is designed for you.
Nitric oxide transports oxygen and nutrients to every cell. When production declines, your mitochondria — the cellular energy factories — literally run low on fuel.
The Nobel Prize-winning research confirmed that NO relaxes and widens arterial walls. Without sufficient NO, blood pressure rises. CircO2 supports the NO pathways that help maintain healthy blood pressure.
Your brain consumes 20% of your body's oxygen. Reduced cerebral blood flow — driven by declining NO — is a primary driver of cognitive fatigue, poor concentration, and memory challenges.
Reduced blood flow to muscles means less oxygen delivery, slower waste clearance, and declining physical performance — especially noticeable in adults over 60.
Research consistently links NO deficiency to arterial stiffness, reduced heart efficiency, and cardiovascular risk. Supporting NO production is one of the most important things you can do for your heart after 40.
Cold hands and feet, numbness, and slow wound healing all signal reduced peripheral circulation — a direct consequence of declining nitric oxide production.
The 1998 Nobel Prize in Physiology or Medicine was awarded to Furchgott, Ignarro, and Murad for their groundbreaking discovery that nitric oxide is the key signaling molecule that tells blood vessels to relax and dilate — controlling blood pressure, oxygen delivery, cognitive function, and physical performance. CircO2 by Advanced Bionutritionals is formulated around this Nobel Prize-validated science, using a unique sublingual lozenge that interacts with oral bacteria to rapidly support NO production.
This is one of America's most trusted formulas in its category — widely recognized and consistently rated among the best-selling supplements by customers who have experienced real results.
The most bioavailable precursor to nitric oxide. Converts to L-Arginine in the kidneys for sustained NO production throughout the day.
Centuries of use for heart health. Research confirms hawthorn supports healthy blood pressure, improves coronary blood flow, and reduces arterial stiffness.
High in dietary nitrates that directly convert to NO via oral bacteria. Research confirms beetroot supplementation measurably improves blood pressure and physical endurance.
Essential for nerve health and energy metabolism. CircO2's sublingual delivery ensures maximum B12 absorption — bypassing digestive absorption issues common in older adults.
Cofactor for 300+ enzymatic reactions including those involved in ATP (energy) production. Magnesium deficiency is extremely common in adults over 60.
"At 74, I feel better than I did at 54. My blood pressure has normalized, my energy is back, and I'm thinking more clearly. CircO2 is the first supplement I've ever felt actually working within the first week."
"My cardiologist was so impressed with my improved circulation markers that he asked what I was doing differently. The answer was CircO2. It dissolves under your tongue and you can feel it working."
"I was skeptical of supplements after wasting money on so many. But Advanced Bionutritionals is a reputable company and the research behind CircO2 is legitimate. Six weeks in — energy is back, blood pressure is down."
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CircO2 by Advanced Bionutritionals comes with a 90-day 100% money-back guarantee. If you don't experience meaningful improvements in energy, circulation, and vitality for any reason within 90 days, return even the empty bottles for a complete refund. No questions asked.
Order Risk-Free Now →Nobel Prize science showed us what drives energy, blood pressure, and vitality. Find out your personal risk level in 30 seconds.
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